Author  
Place of duty  
Title   생식선외 생식세포종 ( Extragonadal Germ Cell Tumor ) 환자에서의 BEP ( Bleomycin , Etoposide , Cisplatin ) 복합화학요법의 치료효과 ( Bleomycin , Etoposide , Cisplatin ( BEP ) Combinatin Chemotherapy for Extragonadal Germ Cell Tumor )
Publicationinfo   1991 Jan; 023(02): 343-350.
Key_word   Extragondal germ cell tumor, BEP regimen
Full-Text  
Abstract   In patients with primary extragonadal germ cell tumor, treatment with combination chemotherapy followed by surgical resection of residual tumor is usually regarded as standard therapy, but the best treatment for such patients still remains a problem. Between November 1987 and October 1989, 8 patients with extragonadal germ cell tumor (7 mediastinal and 1 retroperitoneal) were treated with bleomycin, etoposide and cisplatin (BEP). Four (50%) are alive, 2(25%) with no evidence of disease and overall survuval time was 3.7-30 months (median 9.9 months). Toxicity of chemotherapy was relatively severe. In 71% of the cycles leukopenia was developed and all patients experienced nausea, vomiting and alopecia. Neurotoxicity was observed in 25% of patients and pulmonary toxicity in 50%. We conclude that the BEP regimen has relatively good activity in patients with extragonadal germ ceil tumor, but advanced disease at presentation contributes to the poorer prognosis for these patients. Earlier diagnosis and appropriate surgical resection may improve the long-term survival of patients with this disease.
저 자   강원기(Won Ki Kang),서창인(Chang In Suh),박영석(Young Suk Park),임영혁(Young Hyuk Im),김흥태(Heung Tae Kim),허대석(Dae Seog Heo),방영주(Yung Jue Bang),김노경(Noe Kyeong Kim)